Spazgan - instructions for use, indications, composition, release form, side effects, analogues and price. Spazgan: instructions for use and what it is needed for, price, reviews, analogues. Spazgan: instructions for use
"Spazgan" - a medicinal product combined type, has an analgesic effect and antispasmodic effect.
What is the composition and release form of the drug Spazgan?
The drug Spazgan is produced in tablets, where active ingredients are represented by three substances, I will list these compounds: metamizole sodium, pitofenone hydrochloride is added, and there is also fenpiverinium bromide. In addition, auxiliary and formative ingredients are present in tablet form.
The medicine is placed in packages; it must be stored in a dry place where the temperature should not rise above 25 degrees. Shelf life is three years.
In addition to tablets, the pharmaceutical industry produces the drug Spazgan in the form of a clear solution. It must be kept away from children. The drug is sold in the prescription department.
What is the effect of Spazgan tablets and solution?
The pharmacological action of Spazgan is due to the active substances that are present in the medication. The drug collectively has analgesic, antispasmodic, analgesic, and antipyretic effects.
The non-narcotic analgesic is represented by metamizole sodium, it belongs to pyrazolone derivatives, has an analgesic effect on the body, in addition, antipyretic, and the anti-inflammatory effect of this substance has also been revealed.
Pitophenone hydrochloride has a myotropic effect, that is, it promotes sufficient relaxation of the smooth muscles of the organs. Fenpiverinium bromide has an anticholinergic effect.
Combination of three active substances leads to a mutual strengthening of their effects on the body. The result is pain relief. Smooth muscles relax, and the patient's temperature drops.
What are the indications for use of the drug Spazgan?
The drug Spazgan is indicated for use in pain syndrome developing against the background of smooth muscle spasm in the following situations:
Renal and biliary colic;
At intestinal spasm;
For dysmenorrhea;
As symptomatic remedy for joint pain;
For neuralgia, sciatica;
For muscle pain;
As aid after operations or diagnostic procedures when the patient has severe pain syndrome.
In addition, the drug Spazgan is effective in reducing fever during colds and in inflammatory and infectious pathologies.
What are the contraindications for use of Spazgan?
The instructions for use of Spazgan do not allow use in the following situations:
For tachyarrhythmia;
Collapse;
At hypersensitivity to the substances of this medicine;
Megacolon;
Severe pathology liver or kidneys;
Intestinal obstruction;
Lactation;
Angle-closure glaucoma;
Hypertrophy prostate gland;
Pregnancy;
Some blood diseases.
In addition, Spazgan is not prescribed in pediatrics, in particular under five years of age.
What are the uses and dosage of the medicine Spazgan?
The medication Spazgan is prescribed orally after meals, usually 1 or 2 tablets up to a maximum of six times a day. The duration of taking the medication should not exceed five days. Increasing the duration of treatment can only be done on the recommendation of a doctor.
Spazgan solution is administered parenterally, in particular into a vein and intramuscularly. The daily dose should not be more than ten milliliters. The duration of treatment is also five days. The solution in the ampoule must be warmed in your hand before administration; the medicine should not be administered cold.
This medicine should be administered with caution to patients prone to low blood pressure, that is, to hypotension, as well as bronchospasm. It is worth noting that metamizole metabolites often turn urine reddish.
The simultaneous use of the drug Spazgan with other non-narcotic analgesics often leads to mutual reinforcement toxic effect. Tricyclic antidepressants, allopurinol, and contraceptives increase the toxicity of metamizole.
Barbiturates and phenylbutazone weaken the effect of metamizole. The analgesic effect can be enhanced when Spazgan is used together with sedatives and tranquilizers. If it is necessary to use this medicine together with other drugs, it is important to consult a doctor.
What are Spazgan's side effects?
IN therapeutic doses Spazgan, which we continue to talk about on this page www.site, is well tolerated, but sometimes there may be side effects medication, in particular allergic reactions occur (skin rash, itching, anaphylactic shock). In addition, patients may feel some burning in the epigastric area, dry mouth is characteristic, and there is also headache.
In addition to the listed negative effects, the patient develops dizziness, a decrease in blood pressure, tachycardia, and cyanosis are observed. At long-term use medications Spazgan, changes in blood parameters are possible, in particular, agranulocytosis, thrombocytopenia, as well as leukopenia are noted.
How to replace Spazgan, what analogues should I use?
The drug Bioralgin,
Toothache is a nuisance that everyone has encountered. It is almost always unexpected and unbearable. To get rid of it, you need to have good and effective remedy, which acts quickly and helps for a long time. One of these drugs is Spazgan. In fact, Spazgan helps not only with dental pain, but also with many other types of pain.
Release form and composition
The medicine Spazgan is available both in tablets and in injection solution. 1 standard tablet of the drug contains 500 mg of metamizole sodium, 5 mg of pitofenone hydrochloride and 0.1 mg of fenpiverinium bromide - those active elements of the drug that fight pain symptoms. Metamizole sodium has analgesic and antipyretic properties. Pitophenone hydrochloride and fenpiverinium bromide have a relaxing effect on smooth muscles. Depending on the form in which this drug is produced, the corresponding amount of excipients is also included in its composition.
What is Spazgan taken for?
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The drug helps well with tooth pain; it is also actively used to relieve severe migraines. However, the main indication for its use is spastic pain syndrome of smooth muscles internal organs abdominal cavity and small pelvis.
Spazgan is used for mild or moderate pain:
Spazgan is an indispensable medicine for reducing pain after various kinds surgical operations. This drug perfectly reduces high fever for colds and infectious-inflammatory diseases.
Dosage of the drug for adults and children
When taking Spazgan, you must strictly adhere to its dosage, which is indicated in the instructions for use of the drug. An individual dosage, which depends on the symptoms, is prescribed by the attending physician. If this drug is taken in tablet form, the medication should be taken after meals with a small amount of water.
- The instructions for use of the drug indicate that adults can take the medicine in quantities of up to 6 tablets per day - 1-2 pcs. 2-3 rubles/day.
- If you plan to treat a teenager aged 12 to 15 years with Spazgan, you should not exceed 4 capsules per day. single dose- 1 PC.
- Children from 8 to 11 years old are given 0.5 tablets at maximum daily dose- 4 pieces, from 5 to 7 years - 0.5 each with a maximum daily dose of 2 pieces.
Important! The maximum daily dose of Spazgan for adults is 6 tablets or 10 ml. drug in solution form.
Contraindications for use
Before starting treatment with Spazgan, contraindications for use are taken into account. Concerning intravenous solution medications, it is prohibited for children under 3 months and babies weighing up to 5 kg. The tablets should not be taken by children under five years of age. General contraindications:
- Hypersensitivity to the components of the drug taken.
- Hepatic and renal failure, which has severe symptoms.
- Pregnancy, especially during the most important periods in fetal development (I and III trimesters).
- Lactation - components of the drug may adversely affect the health of the child.
- Intestinal obstruction.
- Decompensated heart failure.
- Megacolon and colon collapse.
- Spazgan is taken with great caution if the patient has bronchial asthma, urticaria, acute rhinitis and arterial hypotension.
Side effects
If Spazgan is used with high frequency, then its side effects may appear. Among them:
A side effect is a signal that taking Spazgan should be stopped immediately. urgently. For appointment further therapy and treatment unwanted symptoms resulting from frequent use medication, you should consult a doctor.
What else can you take for toothache?
If you experience severe toothache, you should contact your dentist (more details in the article:). However, it happens that a visit to the doctor needs to be postponed and take independent measures to get rid of the trouble that has taken you by surprise. As mentioned above, Spazgan - excellent remedy from this surprise, but if suddenly it is not available at the nearest pharmacy or home medicine cabinet, you can use other medications with the same active ingredient.
INSTRUCTIONS
By medical use drug
Registration number:
ND 42-10816-05
Trade name of the drug:
Spazgan™
Dosage form:
pills
Compound
Each tablet contains:
active substances: metamizole sodium – 500 mg, pitofenone hydrochloride – 5.0 mg, fenpiverinium bromide – 0.1 mg;
Excipients:
lactose – 164,000 mg, magnesium stearate – 5,000 mg, colloidal silicon dioxide – 0.100 mg.
Description
Round, flat, beveled tablets white with slightly yellowish tint, with a dividing line on one side and the “” emblem on the other.
Pharmacotherapeutic group:
non-narcotic analgesic and antispasmodic agent.
ATX code: N02BB52
Pharmacological properties
The drug contains: non-narcotic analgesic metamizole sodium
(analgin), myotropic antispasmodic agent pitofenone
and m-anticholinergic agent fenpiverinium bromide.
Metamizole
is a pyrazolone derivative. It has analgesic, antipyretic and anti-inflammatory effects. Pitophenone
, like papaverine, has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation. Phenpiverinium
due to its m-anticholinergic effect, it has an additional relaxing effect on smooth muscles.
The combination of the three components of the drug leads to pain relief, relaxation smooth muscles, decrease elevated temperature bodies.
Indications for use
Mild or moderate pain syndrome with spasms of smooth muscles of internal organs - renal and hepatic colic, pain spastic nature along the intestine, algodismenorrhea. Can be used for short term symptomatic treatment for joint pain, neuralgia, sciatica, myalgia.
As an adjuvant it can be used to reduce pain after surgical and diagnostic interventions.
If necessary, the drug can be used to reduce elevated body temperature during colds and infectious and inflammatory diseases.
Contraindications
Hypersensitivity to pyrazolone derivatives (butadione, tribuzone), to other components of the drug. Oppression bone marrow hematopoiesis, stable and unstable angina, chronic heart failure in the decompensation stage, severe liver or kidney dysfunction, glucose-6-phosphate dehydrogenase deficiency, tachyarrhythmias, angle-closure glaucoma, prostatic hyperplasia with a tendency to urinary retention, intestinal obstruction and megacolon, granulocytopenia, lactase deficiency, lactose intolerance, glucose-galactose malabsorption, pregnancy, lactation, childhood up to 8 years old.
Directions for use and doses
Adults and children over 14 years old taken orally (preferably after meals), usually 1-2 tablets 3-4 times a day. The daily dose should not exceed 8 tablets. Duration of administration is no more than 5 days.
Increasing the daily dose of the drug or the duration of treatment is possible only on the recommendation and under the supervision of a physician.
Dosages for children. In children, the drug is used only as prescribed by a doctor. Dosage for children - 8-11 years old - one tablet no more than 4 times a day, 12-14 years old - 1-1.5 tablets no more than 4 times a day. Other dosage regimens are possible only after consultation with a doctor.
Precautions for use
Carefully and under the supervision of a physician, the drug should be used in patients with impaired liver or kidney function, with a tendency to arterial hypotension (systolic pressure below 100 mm Hg), bronchospasm, as well as with increased individual sensitivity to non-steroidal anti-inflammatory drugs or non-narcotic analgesics. With long-term (more than a week) use of the drug, it is necessary to monitor the peripheral blood picture (leukocyte content) and functional state liver. If agranulocytosis is suspected or thrombocytopenia is present, the drug should be discontinued.
During treatment with the drug, you should not drink alcohol.
Overdose
In case of an overdose of the drug, there may be following symptoms: vomiting, feeling of dry mouth, change in sweating, impaired accommodation, decreased blood pressure, drowsiness, confusion, impaired liver and kidney function, convulsions. Treatment – gastric lavage, prescription activated carbon, symptomatic therapy.
Side effect
Allergic reactions are possible (urticaria, Quincke's edema); multiform exudative erythema(including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome); burning sensation in epigastric region, dry mouth, headache.
Dizziness, decreased blood pressure, tachycardia, cyanosis, red urine color. With long-term use - thrombocytopenia, leukopenia, agranulocytosis.
Interaction with other drugs
The simultaneous use of SPAZGAN with other non-narcotic analgesics can lead to mutual enhancement of toxic effects. Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole. Simultaneous use with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers enhance the analgesic effect of SPAZGAN. If necessary simultaneous use These and other medications should be consulted with your doctor.
Use during pregnancy and breastfeeding
The use of the drug in nursing mothers requires cessation of breastfeeding.
special instructions
Release form
10 tablets in a blister. 2 blisters with instructions for use in a cardboard box. 10 blisters with an equal number of instructions for use in a cardboard box.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children!
Best before date
3 years. Do not use the drug after the expiration date!
Vacation conditions
Over the counter.
Manufacturer
Wockhard Limited, India
Wockhard Tower Bandra Kurla, Bandra East Complex, Mumbai 400051, India
Consumer complaints should be sent to:
Representative office in the Russian Federation:
119571, Russia, Moscow, Leninsky Prospekt, 148, office 123-124,
Email: [email protected]
The name of the drug Spazgan speaks for itself. Its action is aimed at relieving pain that occurs. The drug has a bright pronounced effect, therefore Spazgan is classified as potent drugs. Take it with caution, as directed and under the supervision of the attending physician, since the drug can cause side effects. Spazgan has a number of contraindications, and an overdose is dangerous, since the components included in the composition have a certain toxicity threshold. There is no antidote.
Spasms can occur even in practically healthy person. It depends on the characteristics of the body, or its predisposition to a particular type of disease. The etiology of spasm is the involuntary contraction of muscle tissue of internal organs. Spasm always occurs accompanied by severe pain. Renal, intestinal, or gastric colic are antispasmodic phenomena of internal organs.
Acute pain accompanies inflammatory processes, both with biliary and. The pain is long lasting. To avoid painful shock, the patient needs to take a fast-acting painkiller. Such a remedy is Spazgan. Indications for use of the drug – any acute manifestation pain other than appendicitis.
The tool is endowed medicinal qualities. He not only situationally struggles with acute attacks spasms, but also prevents their further occurrence, fighting the root cause of their manifestation. Spazgan is prescribed in a course of tablets or in the form of injections for 3 to 5 days. After receiving a course of Spazgan, almost all patients noted an improvement in their well-being and the absence of recurrent pain.
Pharmacology
Spasgan (Spazgan), a non-narcotic drug with analgesic, antipyretic and anti-inflammatory properties. Group non-steroidal drugs directed against inflammatory processes and rheumatic pains. Medicine with a combined composition of the Analgesic-Antipyretic group.
Pharmacodynamics
The drug Spazgan contains:
- Metamizole sodium is a non-narcotic analgesic, a derivative of pyrazolone. It is responsible for relieving pain, reducing temperature, as well as mild anti-inflammatory properties.
- Pitofena hydrochloride is a myotropic antispasmodic agent. Relaxes by direct action smooth muscles muscle tissue. The action extends to all internal organs
- Phenpiverinium bromide is the main choline blocker. An accompanying quality is a weak relaxing effect on muscle tissue.
These three substances, when combined, enhance pharmacological properties each component and contribute to the rapid relief of pain, relaxation of smooth muscles, active reduction high temperature bodies.
The main effect of the drug
Spazgan has a strong antispasmodic effect with an analgesic effect and prolongation for a long period of time. This is facilitated by the suppression effect of prostaglandin H-synthetase caused by pyrazolone. Thanks to its effect, the new formation of prostaglandins is difficult.
Sensitivity to barricadin, responsible for stimulation of nerve endings pain, significantly reduced. As a result, the pain syndrome is relieved, and therefore the spasm is extinguished. Also, metamizole in moderate amount, relieves the reaction to inflammation. The release of prostaglandins into the regulatory system is inhibited general temperature center, against the background of which heat transfer increases with the complete elimination of the symptom of fever. Body temperatures remain normal. Pitofenon has a relaxing effect on the smooth muscles of internal organs, resulting in an analgesic effect that relieves spasms.
Phenpiverinium bromide, which represents a group of M-anticholinergics, exhibits blocking properties nerve endings in the parasympathetic fiber. This action is associated with a decrease general tone smooth muscles of the gastrointestinal tract, gallbladder and urinary ducts. In addition, the action of fenpiverinium bromide is aimed at reducing intestinal motility, which is an additional analgesic effect.
Combined action of the drug. Each of the components enhances the pharmacological effects of each other with synergy dosage forms. When taken orally, the effect of Spazgan occurs within 20-30 minutes, reaching an effective maximum after two hours.
The main elimination of the drug from the body is through urine, minor elimination is through bile.
Release form
Spazgan is produced in two modifications. In tablets packed in a blister in an amount of 10 pcs. A standard cardboard package contains 2 blisters. Composition of one Spazgan tablet:
- metamizole sodium - 500 mg
- pitofenone hydrochloride – 5 mg
- fenpiverinium bromide - 100 mcg.
Injection solution for intravenous administration. Ampoule volume 5 ml. Cellular packaging contains 5 ampoules. Five packs are included in cardboard box. Composition of one ampoule of solution for injection:
- metamizole sodium – 1 g
- pitofenone hydrochloride – 400 mcg
- fenpiverinium bromide – 4 mcg.
Analogs produced in other countries:
- Baralgin
- Spasmablock
- Revalgin
- Plenalgin
- Spasmalgon
- Maxigan
- Baralgetas.
Indications and contraindications
Analogue of Spazgan - Spazmalgon
Spazgan is prescribed symptomatically - in cases of sudden, as well as in general therapy in order to prevent the occurrence of spasms. For stomach, intestinal and renal colic weak and moderate character. For spasms of intestinal smooth muscles, painful periods and in cases of functional or organic dysmenorrhea. Symptomatically Spazgan is prescribed in cases of short-term manifestations pain symptoms for sciatica, neuralgia, myalgia, bursitis and arthritis.
As an adjuvant, Spazgan is prescribed to patients after surgical intervention, and also when a certain form diagnostics for pain relief and biliary dyskinesia. As the main therapy for spastic conditions of internal organs, with hyperthermia, manifestations severe forms migraine.
It is not recommended to take the drug in case of any form of intolerance to any of the components. The drug Spazgan is especially contraindicated for people who have difficulty tolerating pyrazolone derivatives.
Contraindications exist for patients with impaired liver function and those suffering from renal failure.
General contraindications:
- angle-closure glaucoma
- intolerance to the components of the drug or one of them
- hereditary disorders of glucose-6-phosphate dehydrogenase activity
- functional disorders of the liver and kidneys
- liver porphyria
- megacolon and intestinal obstruction
- inability to clot and blood diseases
- adenoma and benign hyperplasia prostate gland
- lactation and pregnancy.
Special recommendations apply to a group of patients prone to hypotension. The drug is not recommended for patients with a reaction to analgesics, as well as for those suffering from bronchial asthma. In the first trimester of pregnancy and when breastfeeding, the drug is prescribed with extreme caution.
Dosage of the drug
When making appointments, the table is taken into account age groups patients:
- For young patients up to one year old, if necessary, Spazgan is administered exclusively intramuscularly at a daily dose not exceeding 1.2 ml.
- Age category from 12 months to 5 years. The dosage of Spazgan depends on the body weight, age of the patient and the degree of pain symptom. Daily dosage- from 0.4 to 3.2 ml.
- Age category 5 - 14 years. For this age category The dosage of the drug is no more than 1 ml per injection. The number of injections per day is recommended by the attending physician, but not more than four times a day.
- The age group from 14 years old belongs to adult category. Patients in this group are prescribed a tablet method of treatment. The patient takes 1-2 tablets depending on body weight four times a day. Of these: in breakfast, lunch and dinner before meals and one dose before bedtime.
The tablets are not chewable, have a bitter taste with a pronounced taste of analgin and are washed down with plenty of still drinking water.
Interaction with other drugs
When combined with other non-narcotic drugs, the analgesic group may cause toxic properties any of the components of the drug. Risk negative effect increases many times over, since each of the components of the drug is in active pharmacological form, and has a certain reaction with the release of toxins when interacting with other components of analgin-like drugs.
The simultaneous use of Spazgan with contraception or tricyclic antidepressants containing allopurinol or codeine. Phenylbutazone and barbiturates can weaken the effect of metamizole, increasing its toxicity, and cause adverse reactions. Derivatives of phenylbutazone and barbituric acid inhibit the effect of Spazgan, as antispasmodic. When Spazgan interacts with cyclosporines, their bioavailability for the body is blocked with a subsequent decrease in its level in the blood plasma.
When interacting with sedatives or tranquilizers, there is a significant increase in the effect of Spazgan as an anesthetic. Simultaneous use H1-blockers with histamine, amantadine, tricyclic antidepressants or quinidine, the M-choline blocking properties of Spazgan are significantly enhanced. When interacting with alcohol, the effect is mutually enhanced. Antibiotics of the penicillin group are not used when consuming Spazgan.
Spazgan injections are made without mixing with other agents, since the drug is not compatible with any of them.
Drug overdose
In case of overdose, intoxication with pronounced allergic reaction. Intoxication is caused by metamizole, and fenpiverinium bromide causes anticholinergic manifestations in the form allergic manifestations. May come vascular shock. A more rare occurrence of drug overdose may be signs of agranulocytosis. Damage to the cerebral cortex and irreversible gastrointestinal disorders occur extremely rarely. Symptoms of an overdose of Spazgan: confusion, anxiety, sharp pain in the abdominal area, low blood pressure that cannot be corrected, convulsions, impaired renal function, anaphylactic shock.
There is no antidote. Treatment by flushing the body with hemodialysis using forced diuresis, taking sorbents.
Side effects
IN normal conditions Spazgan is quite well tolerated. The reaction to the drug is purely individual:
- A reaction in the form of a rash may occur on the body.
- Dry mouth is often observed.
- A common reaction from taking the drug is headache and a burning sensation in the epigastric region.
- Some patients experience dizziness, periodic tachycardia with a decrease in blood pressure.
- Taking the drug over a long period of time can lead to disorders of the circulatory system.
- With concomitant asthmatic disease, coughing attacks can be provoked.
- From the gastrointestinal tract. Constipation. IN in rare cases Changes in the mucous membranes may be observed.
- From the outside urinary system. Nephritis, redness of urine, anuria.
- From the side of the central nervous system. Accommodation disturbance, dizziness.
- Individual manifestations. Urticaria may occur, skin rashes, blockage of sweat glands.
In conclusion, it should be noted that the drug Spazgan does not tolerate self-prescription. He must be recommended and the drug must be taken under his supervision. The drug is prescribed with caution to patients with renal or liver failure, bronchial asthma, a tendency to hypotension, hypersensitivity to any of the components of the drug, as well as to any non-narcotic analgesics. When taking the drug for more than seven days, you must be tested for peripheral blood, which gives a complete picture of the functioning of the liver.
In the video, a pharmacist talks about the drug Spazgan, about active ingredients, included in its composition, method of application, side effects and contraindications:
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